In Path of Exile 2, Unique items are among the most coveted treasures you can find. Each Unique comes with predetermined modifiers that make it distinct from other items in the same category - sometimes turning an ordinary weapon or armor piece into the cornerstone of an entire build. Whether you're crafting the ultimate boss killer or a farming powerhouse, Uniques often define how your character plays.

 

Currently, there are over 350 Unique items in Path of Exile 2, and farming them all is no easy task. Drops are completely random, meaning you can grind for hours without seeing the item you want. However, one method stands above traditional farming - "Chancing" your Uniques using the Orb of Chance. This simple yet risky crafting mechanic lets you transform ordinary items into potential Uniques of the same base type.

 

In this guide, we'll go over the best Uniques to Chance, explain how Orbs of Chance work, and share practical tips to increase your odds of success when hunting for endgame-defining items.

 

What Makes Uniques in Path of Exile 2 So Valuable

 

Unlike rare or crafted gear, Unique Path of Exile 2 Items feature fixed modifiers that can't be altered. Every drop of the same Unique item carries the same modifiers, with only minor numerical variation. Some Uniques are so powerful they completely reshape entire builds - increasing damage multipliers, modifying skill interactions, or unlocking entirely new playstyles.

 

Because of their build-defining potential, the right Unique can often be worth thousands of Chaos Orbs in trade leagues - which is why learning to target them through Chancing can save you both time and currency.

 

Top 10 Best Uniques to Chance in Path of Exile 2

 

If you're using Orbs of Chance strategically, these are the best Uniques to go after. They're versatile, valuable, and useful across multiple builds.

 

1. Headhunter

 

·(20-30)% increased Stun Threshold

·Has (1-3) Charm Slots

·+(40-60) to maximum Life

·+(20-40) to Strength and Dexterity

·When you kill a Rare monster, you gain its Modifiers for 60 seconds

 

One of the most famous Uniques in Path of Exile, Headhunter, is a chase item for any mapping or farming build.

 

2. Constricting Command

 

·+(80-120) to maximum Life

·(8-12) Life Regeneration per second

·+(10-15) to all Attributes

·Requires (2-5) fewer enemies to be ‘Surrounded'

 

Ideal for melee or tank builds that benefit from surrounding bonuses and sustain.

 

3. Atziri's Acuity

 

·(80-100)% increaseArmorur

·(30-50)% increased Critical Hit Chance

·Leech from Critical Hits is instant

 

A top-tier glove choice for critical-based builds, especially Assassins or Deadeyes.

 

4. Ventor's Gamble

 

·(6-15)% increased Rarity of Items found

·+(0-80) to maximum Life

·(-40-40)% to all Resistances

 

Risk and reward in one ring - high potential, but high variance. Great for farming builds.

 

5. Astramentis

 

·+(50-100) to all Attributes

·-4 Physical Damage taken from Attacks

 

A powerful amulet for attribute-scaling builds, making it a fantastic early Unique to Chance.

 

6. Beacon of Azis

 

·+(10-15) to Spirit

·(+60-100) to Mana

·Critical Hits ignore Enemy Elemental Resistances

 

Perfect for spellcasters looking to shred through elemental defenses.

 

7. Death Rush

 

·+(120-160) to Accuracy Rating

·Leech 5% of Physical Damage as Life

·Gain Onslaught for 4 seconds on Kill

 

A consistent, aggressive ring for melee and bow users.

 

8. Ingenuity

 

·20% of Flask Recovery applied instantly

·(-10-10)% reduced Charm Charges Used

·Increased bonuses from equipped Rings

 

Excellent for utility builds that rely on flask management and hybrid effects.

 

9. Dream Fragments

 

·(20-30)% Cold Resistance

·(30-50)% increased Mana Regeneration Rate

·You cannot be chilled or frozen

 

A classic defensive Unique that protects against freeze-heavy bosses.

 

10. Hand of Wisdom and Action

 

·+(15-25) to Dexterity and Intelligence

·1% increased Attack Speed per 20 Dexterity

·Adds 1-10 Lightning Damage per 20 Intelligence

·Excellent for hybrid stat-scaling melee builds that focus on speed and precision.

 

These Uniques are not only powerful but also highly tradable. Even if you get a roll that doesn't fit your build, you can often sell it for high value on Path of Exile 2's in-game market.

 

How to Use an Orb of Chance in Path of Exile 2

 

The Orb of Chance is a crafting currency that gives a normal (white) item a chance to upgrade into a Magic, Rare, or Unique item. When you use it on a base type that has a Unique version, it can transform into that Unique, though the odds are incredibly low.

 

Here's how it works:

 

·The base item type matters. For example, using an Orb of Chance on a Viper Cap has a chance (however small) to become Constricting Command, since they share the same base.

·You can only change white items (non-magic, non-rare).

·You cannot change corrupted or mirrored items.

·There is no guaranteed success rate, but it's widely believed to be under 1% for Uniques.

 

This system allows players to buy POE2 Currency in bulk, stockpile Orbs of Chance, and mass-Chance target bases in high-density maps for efficient farming.

 

Tips for Efficient Chancing

 

·Farm the correct base type: Always make sure the item base you're using can actually result in your target Unique.

·Use item filters: Highlight desirable bases for easier farming.

·Bulk Chance in batches: The more attempts, the better your odds.

·Don't chance valuable bases you can sell: If the base itself is expensive, it may be better to trade it.

·Remember: luck is streaky. You might use 50 Orbs of Chance without success - or you might hit gold on your first try.

 

Final Thoughts

 

Chancing Uniques in Path of Exile 2 is equal parts strategy and gamble. While the odds may not always be in your favor, targeting the right bases and focusing on build-defining Uniques like Headhunter, Atziri's Acuity, or Astramentis can make the grind worthwhile.

 

With over 350 Uniques in the game and more being added regularly, mastering Orb of Chance farming will remain one of the most rewarding pursuits for players looking to build, trade, and dominate the endgame in Path of Exile 2.